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NKX6-3

GENERAL INFORMATION

Gene name

 NKX6-3

Gene description

 NK6 homeobox 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (stomach, duodenum)
GTEx:Tissue enriched (cerebellum)
FANTOM5:Not detected

Protein evidence

 Evidence at transcript level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA042790
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 NKX6-3 (HGNC Symbol)

Synonyms

 FLJ25169

Description

 NK6 homeobox 3 (HGNC Symbol)

Entrez gene summary

 The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 [PubMed 16326147]).[supplied by OMIM, Mar 2008]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 41645178 - 41650669

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000165066 (version 83.38)

Entrez gene

 157848

UniProt

 A6NJ46 (UniProt - Evidence at transcript level)

neXtProt

 NX_A6NJ46

Antibodypedia

 NKX6-3 antibodies

PROTEIN BROWSER
NKX6-3-001
NKX6-3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKX6-3-001
ENSP00000428361
ENST00000518699
A6NJ46 [Direct mapping]
Homeobox protein Nkx-6.3
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
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 265 aa
28.9 kDa 		No 0
NKX6-3-002
ENSP00000429553
ENST00000524115
A6NJ46 [Direct mapping]
Homeobox protein Nkx-6.3
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001709 [cell fate determination]
GO:0002067 [glandular epithelial cell differentiation]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
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 135 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.