Tissue expression of NLGN4Y - Summary - The Human Protein Atlas

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NLGN4Y

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NLGN4Y
Gene description	Neuroligin 4, Y-linked
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (seminal vesicle, prostate)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (brain)

Protein evidence

Evidence at transcript level

Protein expression

Cytoplasmic positivity in CNS and peripheral ganglia.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA001651
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (seminal vesicle, prostate)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain)

GENE INFORMATION
Gene name	NLGN4Y (HGNC Symbol)
Synonyms	KIAA0951
Description	Neuroligin 4, Y-linked (HGNC Symbol)
Entrez gene summary	This gene encodes a type I membrane protein that belongs to the family of neuroligins, which are cell adhesion molecules present at the postsynaptic side of the synapse, and may be essential for the formation of functional synapses. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Mar 2011]
Chromosome	Y
Cytoband	q11.221
Chromosome location (bp)	14522638 - 14845650
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000165246 (version 83.38)
Entrez gene	22829
UniProt	Q8NFZ3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NFZ3
Antibodypedia	NLGN4Y antibodies

PROTEIN BROWSER

NLGN4Y-001	NLGN4Y-002	NLGN4Y-003	NLGN4Y-005	NLGN4Y-006	NLGN4Y-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NLGN4Y-001 ENSP00000372325 ENST00000382872	Q8NFZ3 [Direct mapping] Neuroligin-4, Y-linked Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007158 [neuron cell-cell adhesion] GO:0007612 [learning] GO:0009986 [cell surface] GO:0014069 [postsynaptic density] GO:0030054 [cell junction] GO:0035176 [social behavior] GO:0042043 [neurexin family protein binding] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0048488 [synaptic vesicle endocytosis] GO:0050804 [modulation of synaptic transmission] GO:0050839 [cell adhesion molecule binding] GO:0071625 [vocalization behavior] GO:0097104 [postsynaptic membrane assembly] GO:0097105 [presynaptic membrane assembly] GO:0097110 [scaffold protein binding] Show all	648 aa 72.9 kDa	No	1
NLGN4Y-002 ENSP00000348169 ENST00000355905	Q8NFZ3 [Direct mapping] Neuroligin-4, Y-linked A0A024R9E7 [Target identity:100%; Query identity:100%] Neuroligin 4, Y-linked, isoform CRA_d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007158 [neuron cell-cell adhesion] GO:0007612 [learning] GO:0009986 [cell surface] GO:0014069 [postsynaptic density] GO:0030054 [cell junction] GO:0035176 [social behavior] GO:0042043 [neurexin family protein binding] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0048488 [synaptic vesicle endocytosis] GO:0050804 [modulation of synaptic transmission] GO:0050839 [cell adhesion molecule binding] GO:0071625 [vocalization behavior] GO:0097104 [postsynaptic membrane assembly] GO:0097105 [presynaptic membrane assembly] GO:0097110 [scaffold protein binding] Show all	816 aa 92 kDa	Yes	1
NLGN4Y-003 ENSP00000372320 ENST00000382868	A6NMU8 [Direct mapping] Neuroligin 4, Y-linked, isoform CRA_c; Neuroligin-4, Y-linked Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0042043 [neurexin family protein binding] Show all	873 aa 98.5 kDa	Yes	1
NLGN4Y-005 ENSP00000342535 ENST00000339174	Q8NFZ3 [Direct mapping] Neuroligin-4, Y-linked A0A024R9E7 [Target identity:100%; Query identity:100%] Neuroligin 4, Y-linked, isoform CRA_d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007158 [neuron cell-cell adhesion] GO:0007612 [learning] GO:0009986 [cell surface] GO:0014069 [postsynaptic density] GO:0030054 [cell junction] GO:0035176 [social behavior] GO:0042043 [neurexin family protein binding] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0048488 [synaptic vesicle endocytosis] GO:0050804 [modulation of synaptic transmission] GO:0050839 [cell adhesion molecule binding] GO:0071625 [vocalization behavior] GO:0097104 [postsynaptic membrane assembly] GO:0097105 [presynaptic membrane assembly] GO:0097110 [scaffold protein binding] Show all	816 aa 92 kDa	Yes	1
NLGN4Y-006 ENSP00000412638 ENST00000413217	H0Y7G6 [Direct mapping] Neuroligin-4, Y-linked Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		236 aa 26.5 kDa	Yes	0
NLGN4Y-201 ENSP00000297967 ENST00000297967	Q8NFZ3 [Direct mapping] Neuroligin-4, Y-linked Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007158 [neuron cell-cell adhesion] GO:0007612 [learning] GO:0009986 [cell surface] GO:0014069 [postsynaptic density] GO:0030054 [cell junction] GO:0035176 [social behavior] GO:0042043 [neurexin family protein binding] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0048488 [synaptic vesicle endocytosis] GO:0050804 [modulation of synaptic transmission] GO:0050839 [cell adhesion molecule binding] GO:0071625 [vocalization behavior] GO:0097104 [postsynaptic membrane assembly] GO:0097105 [presynaptic membrane assembly] GO:0097110 [scaffold protein binding] Show all	256 aa 28.9 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.