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Malignant cells generally displayed moderate cytoplasmic and nuclear staining. Most testicular and several colorectal cancers showed strong immunoreactivity. Prostate, renal and endometrial cancers were weakly stained or negative in a majority of cases.
GENE INFORMATION
Gene name
SLITRK5 (HGNC Symbol)
Synonyms
bA364G4.2, KIAA0918, LRRC11
Description
SLIT and NTRK-like family, member 5 (HGNC Symbol)
Entrez gene summary
Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]
