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SLITRK5

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GENERAL INFORMATION

Gene name

 SLITRK5

Gene description

 SLIT and NTRK-like family, member 5

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus.

RNA cell category

 Cell line enhanced (AF22)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Golgi apparatus (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA013843
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus.

Main location

 Nucleoplasm (supported)

Additional location

 Golgi apparatus (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA013843 A-431 Nucleoplasm
Golgi apparatus
HPA013843 HeLa Nucleoplasm Intensity
HPA013843 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 SLITRK5 (HGNC Symbol)

Synonyms

 bA364G4.2, KIAA0918, LRRC11

Description

 SLIT and NTRK-like family, member 5 (HGNC Symbol)

Entrez gene summary

 Members of the SLITRK family, such as SLITRK5, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK5, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008]

Chromosome

 13

Cytoband

 q31.2

Chromosome location (bp)

 87672615 - 87696272

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165300 (version 83.38)

Entrez gene

 26050

UniProt

 O94991 (UniProt - Evidence at transcript level)

neXtProt

 NX_O94991

Antibodypedia

 SLITRK5 antibodies

PROTEIN BROWSER
SLITRK5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLITRK5-001
ENSP00000366283
ENST00000325089
O94991 [Direct mapping]
SLIT and NTRK-like protein 5
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0007409 [axonogenesis]
GO:0007625 [grooming behavior]
GO:0009410 [response to xenobiotic stimulus]
GO:0016021 [integral component of membrane]
GO:0021756 [striatum development]
GO:0030534 [adult behavior]
GO:0043235 [receptor complex]
GO:0043588 [skin development]
GO:0048813 [dendrite morphogenesis]
GO:0051965 [positive regulation of synapse assembly]
GO:0072358 [cardiovascular system development]
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 958 aa
107.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.