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A majority of gliomas as well as a few hepatocellular carcinomas showed moderate to strong cytoplasmic staining. Remaining tumor cells were generally negative.
GENE INFORMATION
Gene name
HEPACAM (HGNC Symbol)
Synonyms
FLJ25530, GLIALCAM, hepaCAM
Description
Hepatic and glial cell adhesion molecule (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011]
