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HEPACAM

GENERAL INFORMATION

Gene name

 HEPACAM

Gene description

 Hepatic and glial cell adhesion molecule

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, cerebellum)
FANTOM5:Group enriched (brain, hippocampus, caudate, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in CNS and liver.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB025486
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, hippocampus, caudate, cerebellum)

GENE INFORMATION

Gene name

 HEPACAM (HGNC Symbol)

Synonyms

 FLJ25530, GLIALCAM, hepaCAM

Description

 Hepatic and glial cell adhesion molecule (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011]

Chromosome

 11

Cytoband

 q24.2

Chromosome location (bp)

 124919193 - 124936412

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165478 (version 83.38)

Entrez gene

 220296

UniProt

 Q14CZ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14CZ8

Antibodypedia

 HEPACAM antibodies

PROTEIN BROWSER
HEPACAM-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HEPACAM-001
ENSP00000298251
ENST00000298251
Q14CZ8 [Direct mapping]
Hepatocyte cell adhesion molecule
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Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005911 [cell-cell junction]
GO:0007050 [cell cycle arrest]
GO:0007155 [cell adhesion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030424 [axon]
GO:0034613 [cellular protein localization]
GO:0040008 [regulation of growth]
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 416 aa
46 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.