Expression of SKA3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Spindle and kinetochore associated complex subunit 3

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA039272

GENE INFORMATION
Gene name	SKA3 (HGNC Symbol)
Synonyms	C13orf3, MGC4832, RAMA1
Description	Spindle and kinetochore associated complex subunit 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Chromosome	13
Cytoband	q12.11
Chromosome location (bp)	21153595 - 21176602
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165480 (version 83.38)
Entrez gene	221150
UniProt	Q8IX90 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IX90
Antibodypedia	SKA3 antibodies

PROTEIN BROWSER

SKA3-001	SKA3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SKA3-001 ENSP00000319417 ENST00000314759	Q8IX90 [Direct mapping] Spindle and kinetochore-associated protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000940 [condensed chromosome outer kinetochore] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005876 [spindle microtubule] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0031110 [regulation of microtubule polymerization or depolymerization] GO:0051301 [cell division] Show all	412 aa 46.4 kDa	No	0
SKA3-006 ENSP00000382896 ENST00000400018	Q8IX90 [Direct mapping] Spindle and kinetochore-associated protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000940 [condensed chromosome outer kinetochore] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005876 [spindle microtubule] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0031110 [regulation of microtubule polymerization or depolymerization] GO:0051301 [cell division] Show all	388 aa 44 kDa	No	0