Expression of PKNOX2 in cancer - Summary

CANCER ATLAS

Gene description

PBX/knotted 1 homeobox 2

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB034342

GENE INFORMATION
Gene name	PKNOX2
Synonyms
Description	PBX/knotted 1 homeobox 2 (HGNC Symbol)
Entrez gene summary	Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125164687 - 125433389
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165495 (version 83.38)
Entrez gene	63876
UniProt	Q96KN3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96KN3
Antibodypedia	PKNOX2 antibodies

PROTEIN BROWSER

PKNOX2-001	PKNOX2-007	PKNOX2-008	PKNOX2-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PKNOX2-001 ENSP00000298282 ENST00000298282	Q96KN3 [Direct mapping] Homeobox protein PKNOX2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003785 [actin monomer binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0015629 [actin cytoskeleton] GO:0015630 [microtubule cytoskeleton] GO:0043565 [sequence-specific DNA binding] GO:0051015 [actin filament binding] Show all	472 aa 52 kDa	No	0
PKNOX2-007 ENSP00000431599 ENST00000527238	E9PKL2 [Direct mapping] Homeobox protein PKNOX2 Show all	Predicted intracellular proteins Show all		39 aa 4.2 kDa	No	0
PKNOX2-008 ENSP00000434255 ENST00000531212	E9PRB6 [Direct mapping] Homeobox protein PKNOX2 Show all	Predicted intracellular proteins Show all		40 aa 4.2 kDa	No	0
PKNOX2-012 ENSP00000453374 ENST00000558705	H0YLX0 [Direct mapping] Homeobox protein PKNOX2 Show all	Predicted intracellular proteins Show all		98 aa 10.4 kDa	No	0