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PKNOX2

GENERAL INFORMATION

Gene name

 PKNOX2

Gene description

 PBX/knotted 1 homeobox 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB034342
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina)

GENE INFORMATION

Gene name

 PKNOX2

Synonyms

Description

 PBX/knotted 1 homeobox 2 (HGNC Symbol)

Entrez gene summary

 Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]

Chromosome

 11

Cytoband

 q24.2

Chromosome location (bp)

 125164687 - 125433389

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165495 (version 83.38)

Entrez gene

 63876

UniProt

 Q96KN3 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96KN3

Antibodypedia

 PKNOX2 antibodies

PROTEIN BROWSER
PKNOX2-001
PKNOX2-007
PKNOX2-008
PKNOX2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PKNOX2-001
ENSP00000298282
ENST00000298282
Q96KN3 [Direct mapping]
Homeobox protein PKNOX2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003785 [actin monomer binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0043565 [sequence-specific DNA binding]
GO:0051015 [actin filament binding]
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 472 aa
52 kDa 		No 0
PKNOX2-007
ENSP00000431599
ENST00000527238
E9PKL2 [Direct mapping]
Homeobox protein PKNOX2
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Predicted intracellular proteins
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 39 aa
4.2 kDa 		No 0
PKNOX2-008
ENSP00000434255
ENST00000531212
E9PRB6 [Direct mapping]
Homeobox protein PKNOX2
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Predicted intracellular proteins
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 40 aa
4.2 kDa 		No 0
PKNOX2-012
ENSP00000453374
ENST00000558705
H0YLX0 [Direct mapping]
Homeobox protein PKNOX2
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Predicted intracellular proteins
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 98 aa
10.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.