Expression of GFI1B in cancer - Summary

CANCER ATLAS

Gene description

Growth factor independent 1B transcription repressor

Protein class

Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB004420

GENE INFORMATION
Gene name	GFI1B (HGNC Symbol)
Synonyms	ZNF163B
Description	Growth factor independent 1B transcription repressor (HGNC Symbol)
Entrez gene summary	This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Chromosome	9
Cytoband	q34.13
Chromosome location (bp)	132945533 - 132991687
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165702 (version 83.38)
Entrez gene	8328
UniProt	Q5VTD9 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VTD9
Antibodypedia	GFI1B antibodies

PROTEIN BROWSER

GFI1B-001	GFI1B-002	GFI1B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GFI1B-001 ENSP00000361196 ENST00000372123	Q5VTD9 [Direct mapping] Zinc finger protein Gfi-1b Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008283 [cell proliferation] GO:0016363 [nuclear matrix] GO:0016568 [chromatin modification] GO:0030099 [myeloid cell differentiation] GO:0046872 [metal ion binding] GO:0050767 [regulation of neurogenesis] Show all	284 aa 32.4 kDa	No	0
GFI1B-002 ENSP00000361195 ENST00000372122	Q5VTD9 [Direct mapping] Zinc finger protein Gfi-1b Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008283 [cell proliferation] GO:0016363 [nuclear matrix] GO:0016568 [chromatin modification] GO:0030099 [myeloid cell differentiation] GO:0046872 [metal ion binding] GO:0050767 [regulation of neurogenesis] Show all	330 aa 37.5 kDa	No	0
GFI1B-003 ENSP00000344782 ENST00000339463	Q5VTD9 [Direct mapping] Zinc finger protein Gfi-1b Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008283 [cell proliferation] GO:0016363 [nuclear matrix] GO:0016568 [chromatin modification] GO:0030099 [myeloid cell differentiation] GO:0046872 [metal ion binding] GO:0050767 [regulation of neurogenesis] Show all	330 aa 37.5 kDa	No	0