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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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HPRT1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

HPRT1

Gene description

Hypoxanthine phosphoribosyltransferase 1

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA006360 , CAB012200
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Bronchus

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

HPRT1 (HGNC Symbol)

Synonyms

HGPRT, HPRT

Description

Hypoxanthine phosphoribosyltransferase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009]

Chromosome

X

Cytoband

Chromosome location (bp)

134460153 - 134520513

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165704 (version 83.38)

Entrez gene

3251

UniProt

P00492 (UniProt - Evidence at protein level)

neXtProt

NX_P00492

Antibodypedia

HPRT1 antibodies

PROTEIN BROWSER

HPRT1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HPRT1-001
ENSP00000298556
ENST00000298556
P00492 [Direct mapping]
Hypoxanthine-guanine phosphoribosyltransferase
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0001975 [response to amphetamine]
GO:0004422 [hypoxanthine phosphoribosyltransferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006166 [purine ribonucleoside salvage]
GO:0006168 [adenine salvage]
GO:0006178 [guanine salvage]
GO:0007625 [grooming behavior]
GO:0007626 [locomotory behavior]
GO:0009116 [nucleoside metabolic process]
GO:0019835 [cytolysis]
GO:0021756 [striatum development]
GO:0021895 [cerebral cortex neuron differentiation]
GO:0021954 [central nervous system neuron development]
GO:0032263 [GMP salvage]
GO:0032264 [IMP salvage]
GO:0042417 [dopamine metabolic process]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043101 [purine-containing compound salvage]
GO:0043103 [hypoxanthine salvage]
GO:0044281 [small molecule metabolic process]
GO:0045964 [positive regulation of dopamine metabolic process]
GO:0046038 [GMP catabolic process]
GO:0046040 [IMP metabolic process]
GO:0046083 [adenine metabolic process]
GO:0046100 [hypoxanthine metabolic process]
GO:0046651 [lymphocyte proliferation]
GO:0048813 [dendrite morphogenesis]
GO:0051289 [protein homotetramerization]
GO:0052657 [guanine phosphoribosyltransferase activity]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
218 aa
24.6 kDa
No 0

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