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A majority of cancers displayed weak to moderate nuclear and cytoplasmic positivity. Membranous staining was observed in a few cases. Carcinoids, lymphomas and several gliomas along with several renal cell carcinomas and hepatocellular carcinomas were negative.
GENE INFORMATION
Gene name
STOX1 (HGNC Symbol)
Synonyms
C10orf24, FLJ25162
Description
Storkhead box 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014)
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0006351 [transcription, DNA-templated] GO:0007067 [mitotic nuclear division] GO:0008284 [positive regulation of cell proliferation] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0010821 [regulation of mitochondrion organization] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0051301 [cell division] GO:0051881 [regulation of mitochondrial membrane potential] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071500 [cellular response to nitrosative stress] GO:1901858 [regulation of mitochondrial DNA metabolic process] GO:1902882 [regulation of response to oxidative stress] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity]
Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005938 [cell cortex] GO:0006351 [transcription, DNA-templated] GO:0007067 [mitotic nuclear division] GO:0008284 [positive regulation of cell proliferation] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010800 [positive regulation of peptidyl-threonine phosphorylation] GO:0010821 [regulation of mitochondrion organization] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0045787 [positive regulation of cell cycle] GO:0048839 [inner ear development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051301 [cell division] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071500 [cellular response to nitrosative stress] GO:1901858 [regulation of mitochondrial DNA metabolic process] GO:1902882 [regulation of response to oxidative stress] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:1904120 [positive regulation of otic vesicle morphogenesis]
