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STOX1

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GENERAL INFORMATION

Gene name

 STOX1

Gene description

 Storkhead box 1

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol & nucleoli (fibrillar center).

RNA cell category

 Cell line enhanced (AN3-CA)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Nucleoli fibrillar center (supported), Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA037844 , HPA037845
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol & nucleoli (fibrillar center).

Main location

 Nucleoplasm (supported)

Additional location

 Nucleoli fibrillar center (supported), Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA037844 A-431 Nucleoplasm
HPA037844 U-2 OS Nucleoplasm
HPA037844 U-251 MG Nucleoplasm
Nucleoli fibrillar center
Cytosol
HPA037845 A-431 Nucleoplasm
Cytosol Intensity
HPA037845 U-2 OS Nucleoplasm
Cytosol Intensity
HPA037845 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 STOX1 (HGNC Symbol)

Synonyms

 C10orf24, FLJ25162

Description

 Storkhead box 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 68827541 - 68895432

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165730 (version 83.38)

Entrez gene

 219736

UniProt

 Q6ZVD7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6ZVD7

Antibodypedia

 STOX1 antibodies

PROTEIN BROWSER
STOX1-001
STOX1-002
STOX1-003
STOX1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STOX1-001
ENSP00000382121
ENST00000399169
Q6ZVD7 [Direct mapping]
Storkhead-box protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0007067 [mitotic nuclear division]
GO:0008284 [positive regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010821 [regulation of mitochondrion organization]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0051301 [cell division]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071500 [cellular response to nitrosative stress]
GO:1901858 [regulation of mitochondrial DNA metabolic process]
GO:1902882 [regulation of response to oxidative stress]
GO:1904031 [positive regulation of cyclin-dependent protein kinase activity]
Show all
 989 aa
111 kDa 		Yes 0
STOX1-002
ENSP00000298596
ENST00000298596
Q6ZVD7 [Direct mapping]
Storkhead-box protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005938 [cell cortex]
GO:0006351 [transcription, DNA-templated]
GO:0007067 [mitotic nuclear division]
GO:0008284 [positive regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010821 [regulation of mitochondrion organization]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0045787 [positive regulation of cell cycle]
GO:0048839 [inner ear development]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051301 [cell division]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071500 [cellular response to nitrosative stress]
GO:1901858 [regulation of mitochondrial DNA metabolic process]
GO:1902882 [regulation of response to oxidative stress]
GO:1904031 [positive regulation of cyclin-dependent protein kinase activity]
GO:1904120 [positive regulation of otic vesicle morphogenesis]
Show all
 989 aa
111 kDa 		Yes 0
STOX1-003
ENSP00000382118
ENST00000399165
Q6ZVD7 [Direct mapping]
Storkhead-box protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0007067 [mitotic nuclear division]
GO:0008284 [positive regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010821 [regulation of mitochondrion organization]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0051301 [cell division]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071500 [cellular response to nitrosative stress]
GO:1901858 [regulation of mitochondrial DNA metabolic process]
GO:1902882 [regulation of response to oxidative stress]
GO:1904031 [positive regulation of cyclin-dependent protein kinase activity]
Show all
 227 aa
25.4 kDa 		Yes 0
STOX1-004
ENSP00000382115
ENST00000399162
Q6ZVD7 [Direct mapping]
Storkhead-box protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0007067 [mitotic nuclear division]
GO:0008284 [positive regulation of cell proliferation]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010821 [regulation of mitochondrion organization]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0051301 [cell division]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071500 [cellular response to nitrosative stress]
GO:1901858 [regulation of mitochondrial DNA metabolic process]
GO:1902882 [regulation of response to oxidative stress]
GO:1904031 [positive regulation of cyclin-dependent protein kinase activity]
Show all
 169 aa
19.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.