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Malignant melanomas, prostate cancers, liver cancers and a few cases of malignant gliomas displayed moderate to strong cytoplasmic staining. Remaining tumors were in general weakly stained or negative.
Malignant tissues generally showed moderate cytoplasmic and membranous staining. Several cases of malignant melanomas showed strong positivity. Malignant lymphomas were weakly stained or negative.
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
P07949 [Direct mapping] Proto-oncogene tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
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Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004872 [receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007158 [neuron cell-cell adhesion] GO:0007165 [signal transduction] GO:0007497 [posterior midgut development] GO:0010008 [endosome membrane] GO:0010976 [positive regulation of neuron projection development] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030155 [regulation of cell adhesion] GO:0030335 [positive regulation of cell migration] GO:0033619 [membrane protein proteolysis] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0043231 [intracellular membrane-bounded organelle] GO:0043235 [receptor complex] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048265 [response to pain] GO:0061146 [Peyer's patch morphogenesis] GO:0071300 [cellular response to retinoic acid] GO:0072300 [positive regulation of metanephric glomerulus development] GO:0097021 [lymphocyte migration into lymphoid organs] GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]