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RNASE7

GENERAL INFORMATION

Gene name

 RNASE7

Gene description

 Ribonuclease, RNase A family, 7

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (esophagus, skin, tonsil)
GTEx:Group enriched (esophagus, skin, vagina)
FANTOM5:Group enriched (tonsil, esophagus)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in superficial cells of squamous epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA005690 , CAB062560 , CAB068225
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, esophagus)

GENE INFORMATION

Gene name

 RNASE7 (HGNC Symbol)

Synonyms

 RAE1

Description

 Ribonuclease, RNase A family, 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 21042226 - 21044234

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165799 (version 83.38)

Entrez gene

 84659

UniProt

 Q9H1E1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H1E1

Antibodypedia

 RNASE7 antibodies

PROTEIN BROWSER
RNASE7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNASE7-001
ENSP00000298690
ENST00000298690
Q9H1E1 [Direct mapping]
Ribonuclease 7
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0003676 [nucleic acid binding]
GO:0004519 [endonuclease activity]
GO:0004540 [ribonuclease activity]
GO:0005576 [extracellular region]
GO:0009617 [response to bacterium]
GO:0019731 [antibacterial humoral response]
GO:0042834 [peptidoglycan binding]
GO:0045087 [innate immune response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051673 [membrane disruption in other organism]
GO:0070062 [extracellular exosome]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090501 [RNA phosphodiester bond hydrolysis]
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 156 aa
17.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.