Expression of ARHGEF40 in cancer - Summary

CANCER ATLAS

Gene description

Rho guanine nucleotide exchange factor (GEF) 40

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Skin cancer

STAINING SUMMARY

HPA030746	HPA030757

GENE INFORMATION
Gene name	ARHGEF40 (HGNC Symbol)
Synonyms	FLJ10357, solo
Description	Rho guanine nucleotide exchange factor (GEF) 40 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain. Alternatively spliced transcripts that encode different proteins have been described. [provided by RefSeq, Mar 2014]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	21070270 - 21090240
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165801 (version 83.38)
Entrez gene	55701
UniProt	Q8TER5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TER5
Antibodypedia	ARHGEF40 antibodies

PROTEIN BROWSER

ARHGEF40-001	ARHGEF40-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF40-001 ENSP00000298694 ENST00000298694	Q8TER5 [Direct mapping] Rho guanine nucleotide exchange factor 40 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1519 aa 164.7 kDa	No	0
ARHGEF40-004 ENSP00000451335 ENST00000555038	G3V3N2 [Direct mapping] Rho guanine nucleotide exchange factor 40 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		557 aa 58.8 kDa	No	0