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MOAP1

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GENERAL INFORMATION

Gene name

 MOAP1

Gene description

 Modulator of apoptosis 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & cell junctions.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (approved), Cell Junctions (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA000939
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & cell junctions.

Main location

 Nucleus (approved), Cell Junctions (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA000939 MCF7 Nucleus
Cell Junctions
HPA000939 U-2 OS No staining    
HPA000939 U-251 MG No staining    

GENE INFORMATION

Gene name

 MOAP1 (HGNC Symbol)

Synonyms

 MAP-1, PNMA4

Description

 Modulator of apoptosis 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.12

Chromosome location (bp)

 93182196 - 93184928

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165943 (version 83.38)

Entrez gene

 64112

UniProt

 Q96BY2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96BY2

Antibodypedia

 MOAP1 antibodies

PROTEIN BROWSER
MOAP1-001
MOAP1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MOAP1-001
ENSP00000298894
ENST00000298894
Q96BY2 [Direct mapping]
Modulator of apoptosis 1
Show all
Predicted intracellular proteins
Show all
GO:0001844 [protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097190 [apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 351 aa
39.5 kDa 		No 0
MOAP1-002
ENSP00000451594
ENST00000556883
Q96BY2 [Direct mapping]
Modulator of apoptosis 1
Show all
Predicted intracellular proteins
Show all
GO:0001844 [protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097190 [apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 351 aa
39.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.