Expression of HTRA1 in cancer - Summary

CANCER ATLAS

Gene description

HtrA serine peptidase 1

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Skin cancer

STAINING SUMMARY

HPA036655

GENE INFORMATION
Gene name	HTRA1 (HGNC Symbol)
Synonyms	ARMD7, HtrA, IGFBP5-protease, PRSS11
Description	HtrA serine peptidase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.13
Chromosome location (bp)	122461525 - 122514908
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166033 (version 83.38)
Entrez gene	5654
UniProt	Q92743 (UniProt - Evidence at protein level)
neXtProt	NX_Q92743
Antibodypedia	HTRA1 antibodies

PROTEIN BROWSER

HTRA1-001	HTRA1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTRA1-001 ENSP00000357980 ENST00000368984	Q92743 [Direct mapping] Serine protease HTRA1 Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0001890 [placenta development] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030514 [negative regulation of BMP signaling pathway] GO:0031012 [extracellular matrix] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050687 [negative regulation of defense response to virus] GO:0060718 [chorionic trophoblast cell differentiation] GO:0070062 [extracellular exosome] GO:0097187 [dentinogenesis] Show all	480 aa 51.3 kDa	Yes	0
HTRA1-002 ENSP00000412676 ENST00000420892	H0Y7G9 [Direct mapping] Serine protease HTRA1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] Show all	221 aa 23.9 kDa	No	0