Cell atlas - HTRA1 - The Human Protein Atlas

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HTRA1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	HTRA1
Gene description	HtrA serine peptidase 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Cell line enhanced (LHCN-M2, U-87 MG, ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA036655
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (LHCN-M2, U-87 MG, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036655	U-2 OS	Plasma membrane
	HPA036655	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	HTRA1 (HGNC Symbol)
Synonyms	ARMD7, HtrA, IGFBP5-protease, PRSS11
Description	HtrA serine peptidase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.13
Chromosome location (bp)	122461525 - 122514908
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166033 (version 83.38)
Entrez gene	5654
UniProt	Q92743 (UniProt - Evidence at protein level)
neXtProt	NX_Q92743
Antibodypedia	HTRA1 antibodies

PROTEIN BROWSER

HTRA1-001	HTRA1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HTRA1-001 ENSP00000357980 ENST00000368984	Q92743 [Direct mapping] Serine protease HTRA1 Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0001890 [placenta development] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030514 [negative regulation of BMP signaling pathway] GO:0031012 [extracellular matrix] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050687 [negative regulation of defense response to virus] GO:0060718 [chorionic trophoblast cell differentiation] GO:0070062 [extracellular exosome] GO:0097187 [dentinogenesis] Show all	480 aa 51.3 kDa	Yes	0
HTRA1-002 ENSP00000412676 ENST00000420892	H0Y7G9 [Direct mapping] Serine protease HTRA1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] Show all	221 aa 23.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.