Expression of IL25 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Interleukin 25

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB024864

GENE INFORMATION
Gene name	IL25 (HGNC Symbol)
Synonyms	IL-17E, IL-25, IL17E
Description	Interleukin 25 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	23372809 - 23376403
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166090 (version 83.38)
Entrez gene	64806
UniProt	Q9H293 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H293
Antibodypedia	IL25 antibodies

PROTEIN BROWSER

IL25-001	IL25-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL25-001 ENSP00000328111 ENST00000329715	Q9H293 [Direct mapping] Interleukin-25 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0002437 [inflammatory response to antigenic stimulus] GO:0005125 [cytokine activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006954 [inflammatory response] GO:0007166 [cell surface receptor signaling pathway] GO:0008150 [biological_process] GO:0009620 [response to fungus] GO:0009624 [response to nematode] GO:0030222 [eosinophil differentiation] GO:0030380 [interleukin-17E receptor binding] GO:0032616 [interleukin-13 production] GO:0032634 [interleukin-5 production] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	177 aa 20.3 kDa	No	0
IL25-002 ENSP00000380417 ENST00000397242	Q9H293 [Direct mapping] Interleukin-25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005125 [cytokine activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006954 [inflammatory response] GO:0007166 [cell surface receptor signaling pathway] GO:0008150 [biological_process] GO:0030380 [interleukin-17E receptor binding] Show all	161 aa 18.5 kDa	Yes	0