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IL25

GENERAL INFORMATION

Gene name

 IL25

Gene description

 Interleukin 25

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues. Extracellular deposits in kidney.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
CAB024864
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 IL25 (HGNC Symbol)

Synonyms

 IL-17E, IL-25, IL17E

Description

 Interleukin 25 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 23372809 - 23376403

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166090 (version 83.38)

Entrez gene

 64806

UniProt

 Q9H293 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H293

Antibodypedia

 IL25 antibodies

PROTEIN BROWSER
IL25-001
IL25-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL25-001
ENSP00000328111
ENST00000329715
Q9H293 [Direct mapping]
Interleukin-25
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008150 [biological_process]
GO:0009620 [response to fungus]
GO:0009624 [response to nematode]
GO:0030222 [eosinophil differentiation]
GO:0030380 [interleukin-17E receptor binding]
GO:0032616 [interleukin-13 production]
GO:0032634 [interleukin-5 production]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 177 aa
20.3 kDa 		No 0
IL25-002
ENSP00000380417
ENST00000397242
Q9H293 [Direct mapping]
Interleukin-25
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008150 [biological_process]
GO:0030380 [interleukin-17E receptor binding]
Show all
 161 aa
18.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.