Expression of GPT2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glutamic pyruvate transaminase (alanine aminotransferase) 2

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051514

GENE INFORMATION
Gene name	GPT2 (HGNC Symbol)
Synonyms	ALT2
Description	Glutamic pyruvate transaminase (alanine aminotransferase) 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	16
Cytoband	q11.2
Chromosome location (bp)	46884378 - 46931297
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166123 (version 83.38)
Entrez gene	84706
UniProt	Q8TD30 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TD30
Antibodypedia	GPT2 antibodies

PROTEIN BROWSER

GPT2-001	GPT2-002	GPT2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPT2-001 ENSP00000345282 ENST00000340124	Q8TD30 [Direct mapping] Alanine aminotransferase 2 A0A024R6R2 [Target identity:100%; Query identity:100%] Glutamic pyruvate transaminase (Alanine aminotransferase) 2, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004021 [L-alanine:2-oxoglutarate aminotransferase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006103 [2-oxoglutarate metabolic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042851 [L-alanine metabolic process] GO:0042853 [L-alanine catabolic process] GO:0044281 [small molecule metabolic process] Show all	523 aa 57.9 kDa	No	0
GPT2-002 ENSP00000413804 ENST00000440783	Q8TD30 [Direct mapping] Alanine aminotransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004021 [L-alanine:2-oxoglutarate aminotransferase activity] GO:0005759 [mitochondrial matrix] GO:0006103 [2-oxoglutarate metabolic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042851 [L-alanine metabolic process] GO:0042853 [L-alanine catabolic process] GO:0044281 [small molecule metabolic process] Show all	423 aa 47 kDa	No	0
GPT2-004 ENSP00000457475 ENST00000562132	H3BU54 [Direct mapping] Alanine aminotransferase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] Show all	177 aa 19.3 kDa	No	0