Cell atlas - GPT2 - The Human Protein Atlas

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GPT2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	GPT2
Gene description	Glutamic pyruvate transaminase (alanine aminotransferase) 2
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Mitochondria in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA051514
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051514	A-431	Mitochondria	Intensity
	HPA051514	Hep G2	Mitochondria
	HPA051514	U-2 OS	Mitochondria	Intensity

MOUSE CELLS

Main location

Mitochondria

Mouse gene

ENSMUSG00000031700 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA051514	NIH 3T3	Mitochondria

GENE INFORMATION
Gene name	GPT2 (HGNC Symbol)
Synonyms	ALT2
Description	Glutamic pyruvate transaminase (alanine aminotransferase) 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	16
Cytoband	q11.2
Chromosome location (bp)	46884378 - 46931297
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166123 (version 83.38)
Entrez gene	84706
UniProt	Q8TD30 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TD30
Antibodypedia	GPT2 antibodies

PROTEIN BROWSER

GPT2-001	GPT2-002	GPT2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPT2-001 ENSP00000345282 ENST00000340124	Q8TD30 [Direct mapping] Alanine aminotransferase 2 A0A024R6R2 [Target identity:100%; Query identity:100%] Glutamic pyruvate transaminase (Alanine aminotransferase) 2, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004021 [L-alanine:2-oxoglutarate aminotransferase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006103 [2-oxoglutarate metabolic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042851 [L-alanine metabolic process] GO:0042853 [L-alanine catabolic process] GO:0044281 [small molecule metabolic process] Show all	523 aa 57.9 kDa	No	0
GPT2-002 ENSP00000413804 ENST00000440783	Q8TD30 [Direct mapping] Alanine aminotransferase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004021 [L-alanine:2-oxoglutarate aminotransferase activity] GO:0005759 [mitochondrial matrix] GO:0006103 [2-oxoglutarate metabolic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042851 [L-alanine metabolic process] GO:0042853 [L-alanine catabolic process] GO:0044281 [small molecule metabolic process] Show all	423 aa 47 kDa	No	0
GPT2-004 ENSP00000457475 ENST00000562132	H3BU54 [Direct mapping] Alanine aminotransferase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] Show all	177 aa 19.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.