Expression of CKB in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Creatine kinase, brain

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA001254	CAB047313

GENE INFORMATION
Gene name	CKB (HGNC Symbol)
Synonyms	CKBB
Description	Creatine kinase, brain (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	103519659 - 103523111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166165 (version 83.38)
Entrez gene	1152
UniProt	P12277 (UniProt - Evidence at protein level)
neXtProt	NX_P12277
Antibodypedia	CKB antibodies

PROTEIN BROWSER

CKB-001	CKB-006	CKB-010	CKB-016	CKB-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CKB-001 ENSP00000299198 ENST00000348956	P12277 [Direct mapping] Creatine kinase B-type V9HWH2 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 29 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004111 [creatine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006595 [polyamine metabolic process] GO:0006600 [creatine metabolic process] GO:0007420 [brain development] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0021762 [substantia nigra development] GO:0030644 [cellular chloride ion homeostasis] GO:0031625 [ubiquitin protein ligase binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0043209 [myelin sheath] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	381 aa 42.6 kDa	No	0
CKB-006 ENSP00000451611 ENST00000557530	G3V461 [Direct mapping] Creatine kinase B-type Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	128 aa 14.2 kDa	No	0
CKB-010 ENSP00000451904 ENST00000553878	G3V4N7 [Direct mapping] Creatine kinase B-type Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	217 aa 24.1 kDa	No	0
CKB-016 ENSP00000451686 ENST00000555039	H0YJK0 [Direct mapping] Creatine kinase B-type Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	90 aa 9.7 kDa	No	0
CKB-018 ENSP00000451426 ENST00000553610	H0YJG0 [Direct mapping] Creatine kinase B-type Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	179 aa 20.1 kDa	No	0