Cell atlas - CKB - The Human Protein Atlas

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CKB

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	CKB
Gene description	Creatine kinase, brain
Protein class	Cancer-related genes Candidate cardiovascular disease genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (HEK 293, SCLC-21H, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA001254
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEK 293, SCLC-21H, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001254	HEK 293	Cytosol	Intensity
	HPA001254	U-2 OS	Cytosol	Intensity
	HPA001254	U-251 MG	Cytosol	Intensity

GENE INFORMATION
Gene name	CKB (HGNC Symbol)
Synonyms	CKBB
Description	Creatine kinase, brain (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	103519659 - 103523111
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166165 (version 83.38)
Entrez gene	1152
UniProt	P12277 (UniProt - Evidence at protein level)
neXtProt	NX_P12277
Antibodypedia	CKB antibodies

PROTEIN BROWSER

CKB-001	CKB-006	CKB-010	CKB-016	CKB-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CKB-001 ENSP00000299198 ENST00000348956	P12277 [Direct mapping] Creatine kinase B-type V9HWH2 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 29 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004111 [creatine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006595 [polyamine metabolic process] GO:0006600 [creatine metabolic process] GO:0007420 [brain development] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0021762 [substantia nigra development] GO:0030644 [cellular chloride ion homeostasis] GO:0031625 [ubiquitin protein ligase binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0043209 [myelin sheath] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	381 aa 42.6 kDa	No	0
CKB-006 ENSP00000451611 ENST00000557530	G3V461 [Direct mapping] Creatine kinase B-type Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	128 aa 14.2 kDa	No	0
CKB-010 ENSP00000451904 ENST00000553878	G3V4N7 [Direct mapping] Creatine kinase B-type Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	217 aa 24.1 kDa	No	0
CKB-016 ENSP00000451686 ENST00000555039	H0YJK0 [Direct mapping] Creatine kinase B-type Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	90 aa 9.7 kDa	No	0
CKB-018 ENSP00000451426 ENST00000553610	H0YJG0 [Direct mapping] Creatine kinase B-type Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	179 aa 20.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.