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Most malignancies displayed weak cytoplasmic positivity. Malignant melanoma testicular, prostate, colorectal and liver cancers showed moderate cytoplasmic immunoreactivity in some cases. Malignant glioma and lymphoma were mostly negative.
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006281 [DNA repair] GO:0006307 [DNA dealkylation involved in DNA repair] GO:0008198 [ferrous iron binding] GO:0008283 [cell proliferation] GO:0016491 [oxidoreductase activity] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0031418 [L-ascorbic acid binding] GO:0035552 [oxidative single-stranded DNA demethylation] GO:0043734 [DNA-N1-methyladenine dioxygenase activity] GO:0051747 [cytosine C-5 DNA demethylase activity] GO:0055114 [oxidation-reduction process]
