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ALKBH3

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GENERAL INFORMATION

Gene name

 ALKBH3

Gene description

 AlkB homolog 3, alpha-ketoglutarate-dependent dioxygenase

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the mitochondria.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Additional location

 In addition localized to the Mitochondria (uncertain)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA009674 , HPA046489
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the mitochondria.

Main location

 Nucleoplasm (validated)

Additional location

 Mitochondria (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA046489 A-431 Nucleoplasm
HPA046489 U-2 OS No staining    
HPA009674 A-431 Nucleoplasm
Mitochondria
HPA009674 U-2 OS Nucleus
Cytosol
HPA009674 U-251 MG Nucleoplasm
Mitochondria

GENE INFORMATION

Gene name

 ALKBH3 (HGNC Symbol)

Synonyms

 DEPC-1

Description

 AlkB homolog 3, alpha-ketoglutarate-dependent dioxygenase (HGNC Symbol)

Entrez gene summary

 The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 43880811 - 43920266

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166199 (version 83.38)

Entrez gene

 221120

UniProt

 Q96Q83 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96Q83

Antibodypedia

 ALKBH3 antibodies

PROTEIN BROWSER
ALKBH3-001
ALKBH3-007
ALKBH3-010
ALKBH3-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALKBH3-001
ENSP00000302232
ENST00000302708
Q96Q83 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006307 [DNA dealkylation involved in DNA repair]
GO:0008198 [ferrous iron binding]
GO:0008283 [cell proliferation]
GO:0016491 [oxidoreductase activity]
GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors]
GO:0031418 [L-ascorbic acid binding]
GO:0035552 [oxidative single-stranded DNA demethylation]
GO:0043734 [DNA-N1-methyladenine dioxygenase activity]
GO:0051747 [cytosine C-5 DNA demethylase activity]
GO:0055114 [oxidation-reduction process]
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 286 aa
33.4 kDa 		No 0
ALKBH3-007
ENSP00000434229
ENST00000524742
E9PRD0 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 60 aa
7 kDa 		No 0
ALKBH3-010
ENSP00000435848
ENST00000529366
E9PSA5 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
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 223 aa
25.9 kDa 		No 0
ALKBH3-012
ENSP00000433614
ENST00000532129
H0YDH4 [Direct mapping]
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 156 aa
18.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.