Expression of C2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Complement component 2

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB016775

GENE INFORMATION
Gene name	C2
Synonyms
Description	Complement component 2 (HGNC Symbol)
Entrez gene summary	Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31897785 - 31945672
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166278 (version 83.38)
Entrez gene	717
UniProt	P06681 (UniProt - Evidence at protein level)
neXtProt	NX_P06681
Antibodypedia	C2 antibodies

PROTEIN BROWSER

C2-001	C2-002	C2-003	C2-004	C2-007	C2-009	C2-010	C2-011	C2-014	C2-015	C2-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C2-001 ENSP00000299367 ENST00000299367	P06681 [Direct mapping] Complement C2 Complement C2b fragment Complement C2a fragment Q5JP69 [Target identity:100%; Query identity:100%] Complement component 2, isoform CRA_b; cDNA, FLJ92956, Homo sapiens complement component 2 (C2), mRNA Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0007584 [response to nutrient] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:2000427 [positive regulation of apoptotic cell clearance] Show all	752 aa 83.3 kDa	Yes	0
C2-002 ENSP00000406190 ENST00000418949	Q8N6L6 [Direct mapping] C2 protein; Complement C2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		328 aa 35.5 kDa	Yes	0
C2-003 ENSP00000372664 ENST00000383177	H0Y3H6 [Direct mapping] Complement C2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	526 aa 58.8 kDa	Yes	0
C2-004 ENSP00000417482 ENST00000497706	E9PDZ0 [Direct mapping] Complement C2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	463 aa 51.4 kDa	No	0
C2-007 ENSP00000403325 ENST00000413154	Q5ST52 [Direct mapping] Complement C2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 14.8 kDa	Yes	0
C2-009 ENSP00000391354 ENST00000447952	F2Z3N2 [Direct mapping] Complement C2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		203 aa 21.7 kDa	Yes	0
C2-010 ENSP00000395683 ENST00000442278	P06681 [Direct mapping] Complement C2 Complement C2b fragment Complement C2a fragment Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:2000427 [positive regulation of apoptotic cell clearance] Show all	620 aa 69.4 kDa	Yes	0
C2-011 ENSP00000419048 ENST00000494905	C9JYQ5 [Direct mapping] Complement C2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 14.9 kDa	No	0
C2-014 ENSP00000392322 ENST00000452323	P06681 [Direct mapping] Complement C2 Complement C2b fragment Complement C2a fragment Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:2000427 [positive regulation of apoptotic cell clearance] Show all	538 aa 60.3 kDa	No	0
C2-015 ENSP00000406121 ENST00000452202	A2ABG0 [Direct mapping] Complement C2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 17.5 kDa	No	0
C2-017 ENSP00000418923 ENST00000469372	B4DQI1 [Direct mapping] Complement C2; cDNA FLJ54376, highly similar to Complement C2 (EC 3.4.21.43) Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	506 aa 56.5 kDa	No	0