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APBB1

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GENERAL INFORMATION

Gene name

 APBB1

Gene description

 Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 16
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the plasma membrane.

RNA cell category

 Cell line enhanced (SCLC-21H)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (validated)

Mouse

 Localized to the Plasma membrane, Cytosol in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA038521 , HPA038522
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the plasma membrane.

Main location

 Plasma membrane (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA038521 HEK 293 Plasma membrane
HPA038521 U-2 OS Plasma membrane
HPA038521 U-251 MG No staining    
HPA038522 U-2 OS Plasma membrane
HPA038522 U-251 MG Plasma membrane

MOUSE CELLS

Main location

 Plasma membrane, Cytosol

Mouse gene

 ENSMUSG00000037032 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA038521 NIH 3T3 Plasma membrane
Cytosol

GENE INFORMATION

Gene name

 APBB1 (HGNC Symbol)

Synonyms

 Fe65, RIR

Description

 Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 11

Cytoband

 p15.4

Chromosome location (bp)

 6395124 - 6419414

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166313 (version 83.38)

Entrez gene

 322

UniProt

 O00213 (UniProt - Evidence at protein level)

neXtProt

 NX_O00213

Antibodypedia

 APBB1 antibodies

PROTEIN BROWSER
«
APBB1-001
APBB1-002
APBB1-004
APBB1-005
APBB1-006
APBB1-007
APBB1-014
APBB1-018
APBB1-023
APBB1-024
APBB1-025
APBB1-026
APBB1-201
APBB1-202
APBB1-203
APBB1-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APBB1-001
ENSP00000311912
ENST00000311051
O00213 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008134 [transcription factor binding]
GO:0016607 [nuclear speck]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0042393 [histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0045202 [synapse]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050760 [negative regulation of thymidylate synthase biosynthetic process]
GO:0070064 [proline-rich region binding]
Show all
 708 aa
77 kDa 		No 0
APBB1-002
ENSP00000299402
ENST00000299402
O00213 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008134 [transcription factor binding]
GO:0016607 [nuclear speck]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0042393 [histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0045202 [synapse]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050760 [negative regulation of thymidylate synthase biosynthetic process]
GO:0070064 [proline-rich region binding]
Show all
 708 aa
77 kDa 		No 0
APBB1-004
ENSP00000476536
ENST00000529890
V9GY97 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008134 [transcription factor binding]
Show all
 262 aa
29.2 kDa 		No 0
APBB1-005
ENSP00000476442
ENST00000608394
O00213 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008134 [transcription factor binding]
GO:0016607 [nuclear speck]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0042393 [histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0045202 [synapse]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050760 [negative regulation of thymidylate synthase biosynthetic process]
GO:0070064 [proline-rich region binding]
Show all
 451 aa
49.9 kDa 		No 0
APBB1-006
ENSP00000477022
ENST00000529519
V9GYR7 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008134 [transcription factor binding]
Show all
 235 aa
25.7 kDa 		No 0
APBB1-007
ENSP00000433338
ENST00000530885
O00213 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008134 [transcription factor binding]
GO:0016607 [nuclear speck]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0042393 [histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0045202 [synapse]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050760 [negative regulation of thymidylate synthase biosynthetic process]
GO:0070064 [proline-rich region binding]
Show all
 488 aa
53.9 kDa 		Yes 0
APBB1-014
ENSP00000476871
ENST00000608704
O00213 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008134 [transcription factor binding]
GO:0016607 [nuclear speck]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0042393 [histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0045202 [synapse]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050760 [negative regulation of thymidylate synthase biosynthetic process]
GO:0070064 [proline-rich region binding]
Show all
 451 aa
49.9 kDa 		No 0
APBB1-018
ENSP00000477069
ENST00000609331
O00213 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008134 [transcription factor binding]
GO:0016607 [nuclear speck]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0042393 [histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0045202 [synapse]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050760 [negative regulation of thymidylate synthase biosynthetic process]
GO:0070064 [proline-rich region binding]
Show all
 475 aa
52.7 kDa 		No 0
APBB1-023
ENSP00000477213
ENST00000609360
O00213 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008134 [transcription factor binding]
GO:0010039 [response to iron ion]
GO:0010976 [positive regulation of neuron projection development]
GO:0016607 [nuclear speck]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0032403 [protein complex binding]
GO:0042393 [histone binding]
GO:0042734 [presynaptic membrane]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043234 [protein complex]
GO:0043967 [histone H4 acetylation]
GO:0044304 [main axon]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045739 [positive regulation of DNA repair]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0050760 [negative regulation of thymidylate synthase biosynthetic process]
GO:0070064 [proline-rich region binding]
GO:1990761 [growth cone lamellipodium]
GO:1990812 [growth cone filopodium]
Show all
 710 aa
77.2 kDa 		No 0
APBB1-024
ENSP00000476846
ENST00000608655
O00213 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008134 [transcription factor binding]
GO:0016607 [nuclear speck]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0042393 [histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0045202 [synapse]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050760 [negative regulation of thymidylate synthase biosynthetic process]
GO:0070064 [proline-rich region binding]
Show all
 490 aa
54.2 kDa 		Yes 0
APBB1-025
ENSP00000476646
ENST00000608645
O00213 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007409 [axonogenesis]
GO:0008134 [transcription factor binding]
GO:0016607 [nuclear speck]
GO:0030027 [lamellipodium]
GO:0030308 [negative regulation of cell growth]
GO:0030426 [growth cone]
GO:0042393 [histone binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043967 [histone H4 acetylation]
GO:0045202 [synapse]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050760 [negative regulation of thymidylate synthase biosynthetic process]
GO:0070064 [proline-rich region binding]
Show all
 451 aa
49.9 kDa 		No 0
APBB1-026
ENSP00000476647
ENST00000532020
V9GYD5 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008134 [transcription factor binding]
Show all
 87 aa
9.7 kDa 		No 0
APBB1-201
ENSP00000374556
ENST00000389906
J3KPL8 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0008134 [transcription factor binding]
Show all
 710 aa
77.2 kDa 		No 0
APBB1-202
ENSP00000483682
ENST00000610474
A0A087X0V7 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008134 [transcription factor binding]
Show all
 451 aa
49.8 kDa 		No 0
APBB1-203
ENSP00000484493
ENST00000618005
A0A087X0V7 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008134 [transcription factor binding]
Show all
 451 aa
49.8 kDa 		No 0
APBB1-204
ENSP00000481817
ENST00000621678
A0A087WYH9 [Direct mapping]
Amyloid beta A4 precursor protein-binding family B member 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008134 [transcription factor binding]
Show all
 475 aa
52.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.