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A majority of cancers showed moderate to strong cytoplasmic positivity in granular pattern. Colorectal cancers exhibited distinct extracellular positivity. Few cases of lymphomas and squamous cell carcinomas were negative.
Cancer tissues displayed moderate to strong cytoplasmic positivity with a granular pattern.
GENE INFORMATION
Gene name
CASC4 (HGNC Symbol)
Synonyms
DKFZp459F1927, H63
Description
Cancer susceptibility candidate 4 (HGNC Symbol)
Entrez gene summary
The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
