Cell atlas - CASC4 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CASC4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CASC4
Gene description	Cancer susceptibility candidate 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA043015 , HPA049488
	SHOW MORE

ASSAYS

RNA expression

Human cells

Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA043015	A-431	Golgi apparatus
HPA043015	U-2 OS	Golgi apparatus
HPA043015	U-251 MG	Golgi apparatus
HPA049488	A-431	Golgi apparatus
HPA049488	U-2 OS	Golgi apparatus
HPA049488	U-251 MG	Golgi apparatus

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA049488	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) after the treatment of U-2 OS cells with brefeldin A (5 ug/ml) for 30 minutes to disrupt the ER to Golgi transport; GOLGA2 localizes together with proteins associated with the Golgi-matrix (PMID: 8557739). CASC4 shuttles between ER and Golgi apparatus, as it is found in the ER after the transport is disrupted by BFA treatment.
	HPA049488	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. CASC4 localizes to the Golgi apparatus, but not to the cis-Golgi compartment.

GENE INFORMATION
Gene name	CASC4 (HGNC Symbol)
Synonyms	DKFZp459F1927, H63
Description	Cancer susceptibility candidate 4 (HGNC Symbol)
Entrez gene summary	The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
Chromosome	15
Cytoband	q15.3
Chromosome location (bp)	44288729 - 44415758
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166734 (version 83.38)
Entrez gene	113201
UniProt	Q6P4E1 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P4E1
Antibodypedia	CASC4 antibodies

PROTEIN BROWSER

CASC4-001	CASC4-002	CASC4-006	CASC4-009	CASC4-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CASC4-001 ENSP00000299957 ENST00000299957	Q6P4E1 [Direct mapping] Protein CASC4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0016021 [integral component of membrane] Show all	436 aa 49.5 kDa	No	0
CASC4-002 ENSP00000335063 ENST00000345795	Q6P4E1 [Direct mapping] Protein CASC4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] GO:0016021 [integral component of membrane] Show all	380 aa 43.3 kDa	No	0
CASC4-006 ENSP00000453703 ENST00000559222	H0YMR0 [Direct mapping] Protein CASC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005794 [Golgi apparatus] Show all	113 aa 13.5 kDa	No	0
CASC4-009 ENSP00000453465 ENST00000558847	H0YM51 [Direct mapping] Protein CASC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 17.8 kDa	No	0
CASC4-011 ENSP00000452833 ENST00000561305	H0YKJ7 [Direct mapping] Protein CASC4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		24 aa 2.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.