Fields »
ABOUT
HELP
BLOG
AP1G1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 AP1G1

Gene description

 Adaptor-related protein complex 1, gamma 1 subunit

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to vesicles. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (validated)

Additional location

 In addition localized to the Cytosol (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

Mouse

 Localized to the Golgi apparatus, Vesicles in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA041224
SHOW MORE

ASSAYS
RNA expression
Human cells
siRNA
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to vesicles. In addition localized to the cytosol.

Main location

 Vesicles (validated)

Additional location

 Cytosol (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA041224 A-431 Vesicles
Cytosol
HPA041224 MCF7 Vesicles
Cytosol
HPA041224 U-2 OS Vesicles

siRNA VALIDATION
 

Relative fluorescence intensity (RFI)

Antibody

 HPA041224

siRNA validation

 Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

 Cytoplasmic region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

 44%51%

p-value

 < 0.01< 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA041224 siRNA 2 U-2 OS
HPA041224 scrambled U-2 OS
HPA041224 siRNA 1 U-2 OS

MOUSE CELLS

Main location

 Golgi apparatus, Vesicles

Mouse gene

 ENSMUSG00000031731 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA041224 NIH 3T3 Golgi apparatus
Vesicles

GENE INFORMATION

Gene name

 AP1G1 (HGNC Symbol)

Synonyms

 ADTG, CLAPG1

Description

 Adaptor-related protein complex 1, gamma 1 subunit (HGNC Symbol)

Entrez gene summary

 Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.2

Chromosome location (bp)

 71729000 - 71809201

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166747 (version 83.38)

Entrez gene

 164

UniProt

 O43747 (UniProt - Evidence at protein level)

neXtProt

 NX_O43747

Antibodypedia

 AP1G1 antibodies

PROTEIN BROWSER
«
AP1G1-001
AP1G1-002
AP1G1-008
AP1G1-014
AP1G1-016
AP1G1-017
AP1G1-020
AP1G1-021
AP1G1-022
AP1G1-024
AP1G1-025
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP1G1-001
ENSP00000299980
ENST00000299980
O43747 [Direct mapping]
AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0017137 [Rab GTPase binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019894 [kinesin binding]
GO:0030117 [membrane coat]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030136 [clathrin-coated vesicle]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0030742 [GTP-dependent protein binding]
GO:0032438 [melanosome organization]
GO:0032588 [trans-Golgi network membrane]
GO:0035646 [endosome to melanosome transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043323 [positive regulation of natural killer cell degranulation]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0050690 [regulation of defense response to virus by virus]
GO:0055037 [recycling endosome]
GO:0061024 [membrane organization]
GO:0090160 [Golgi to lysosome transport]
Show all
 822 aa
91.4 kDa 		No 0
AP1G1-002
ENSP00000454523
ENST00000569748
O43747 [Direct mapping]
AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0017137 [Rab GTPase binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019894 [kinesin binding]
GO:0030117 [membrane coat]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030136 [clathrin-coated vesicle]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0030742 [GTP-dependent protein binding]
GO:0032438 [melanosome organization]
GO:0032588 [trans-Golgi network membrane]
GO:0035646 [endosome to melanosome transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043323 [positive regulation of natural killer cell degranulation]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0050690 [regulation of defense response to virus by virus]
GO:0055037 [recycling endosome]
GO:0061024 [membrane organization]
GO:0090160 [Golgi to lysosome transport]
Show all
 822 aa
91.4 kDa 		No 0
AP1G1-008
ENSP00000454219
ENST00000564155
B3KNW1 [Direct mapping]
AP-1 complex subunit gamma-1; cDNA FLJ30560 fis, clone BRAWH2004217, highly similar to AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030131 [clathrin adaptor complex]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 247 aa
26.3 kDa 		No 0
AP1G1-014
ENSP00000377148
ENST00000393512
O43747 [Direct mapping]
AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005215 [transporter activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0017137 [Rab GTPase binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019894 [kinesin binding]
GO:0030117 [membrane coat]
GO:0030119 [AP-type membrane coat adaptor complex]
GO:0030131 [clathrin adaptor complex]
GO:0030136 [clathrin-coated vesicle]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0030742 [GTP-dependent protein binding]
GO:0032438 [melanosome organization]
GO:0032588 [trans-Golgi network membrane]
GO:0035646 [endosome to melanosome transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043323 [positive regulation of natural killer cell degranulation]
GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050690 [regulation of defense response to virus by virus]
GO:0055037 [recycling endosome]
GO:0061024 [membrane organization]
GO:0090160 [Golgi to lysosome transport]
Show all
 825 aa
91.7 kDa 		No 0
AP1G1-016
ENSP00000455400
ENST00000570017
H3BPN9 [Direct mapping]
AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 26 aa
3.1 kDa 		No 0
AP1G1-017
ENSP00000457927
ENST00000567583
H3BV30 [Direct mapping]
AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 92 aa
10.8 kDa 		No 0
AP1G1-020
ENSP00000454713
ENST00000563104
H3BN71 [Direct mapping]
AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 145 aa
16.6 kDa 		No 0
AP1G1-021
ENSP00000456316
ENST00000569185
H3BRM7 [Direct mapping]
AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 140 aa
16 kDa 		No 0
AP1G1-022
ENSP00000456058
ENST00000563259
H3BR36 [Direct mapping]
AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 187 aa
21.4 kDa 		No 0
AP1G1-024
ENSP00000454717
ENST00000569975
H3BN75 [Direct mapping]
AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 53 aa
6.3 kDa 		No 0
AP1G1-025
ENSP00000456493
ENST00000565412
H3BS13 [Direct mapping]
AP-1 complex subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0006886 [intracellular protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 85 aa
10 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.