Cell atlas - PLIN1 - The Human Protein Atlas

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PLIN1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Peroxisomes

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	PLIN1
Gene description	Perilipin 1
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the peroxisome.
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Localized to the Peroxisomes (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA024299
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the peroxisome.

Main location

Peroxisomes (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024299	A-431	Peroxisomes
	HPA024299	U-2 OS	Peroxisomes
	HPA024299	U-251 MG	Peroxisomes

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA024299	U-2 OS	Image	PLIN1 localizes to peroxisomes, as it co-localizes with the peroxisomal marker ABCD3.

GENE INFORMATION
Gene name	PLIN1 (HGNC Symbol)
Synonyms	PLIN
Description	Perilipin 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009]
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	89664365 - 89679427
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166819 (version 83.38)
Entrez gene	5346
UniProt	O60240 (UniProt - Evidence at protein level)
neXtProt	NX_O60240
Antibodypedia	PLIN1 antibodies

PROTEIN BROWSER

PLIN1-001	PLIN1-003	PLIN1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLIN1-001 ENSP00000300055 ENST00000300055	O60240 [Direct mapping] Perilipin-1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005811 [lipid particle] GO:0006629 [lipid metabolic process] GO:0008289 [lipid binding] GO:0019433 [triglyceride catabolic process] GO:0044281 [small molecule metabolic process] Show all	522 aa 56 kDa	No	0
PLIN1-003 ENSP00000402167 ENST00000430628	O60240 [Direct mapping] Perilipin-1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005811 [lipid particle] GO:0006629 [lipid metabolic process] GO:0008289 [lipid binding] GO:0019433 [triglyceride catabolic process] GO:0044281 [small molecule metabolic process] Show all	522 aa 56 kDa	No	0
PLIN1-005 ENSP00000453426 ENST00000560330	H0YM16 [Direct mapping] Perilipin-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	73 aa 7.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.