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DCTN5

CANCER ATLAS

Gene description

 Dynactin 5 (p25)

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042003

GENE INFORMATION

Gene name

 DCTN5 (HGNC Symbol)

Synonyms

 MGC3248, p25

Description

 Dynactin 5 (p25) (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 16

Cytoband

 p12.2

Chromosome location (bp)

 23641392 - 23677455

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166847 (version 83.38)

Entrez gene

 84516

UniProt

 Q9BTE1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BTE1

Antibodypedia

 DCTN5 antibodies

PROTEIN BROWSER
DCTN5-001
DCTN5-003
DCTN5-004
DCTN5-005
DCTN5-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DCTN5-001
ENSP00000300087
ENST00000300087
Q9BTE1 [Direct mapping]
Dynactin subunit 5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000777 [condensed chromosome kinetochore]
GO:0003281 [ventricular septum development]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0035904 [aorta development]
GO:0060976 [coronary vasculature development]
Show all
 182 aa
20.1 kDa 		No 0
DCTN5-003
ENSP00000455685
ENST00000568272
Q9BTE1 [Direct mapping]
Dynactin subunit 5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
Show all
 84 aa
9.7 kDa 		No 0
DCTN5-004
ENSP00000458354
ENST00000566298
I3L0U8 [Direct mapping]
Dynactin subunit 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 99 aa
11 kDa 		No 0
DCTN5-005
ENSP00000456137
ENST00000568589
H3BR94 [Direct mapping]
Dynactin subunit 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 155 aa
16.9 kDa 		No 0
DCTN5-009
ENSP00000454691
ENST00000563998
Q9BTE1 [Direct mapping]
Dynactin subunit 5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
Show all
 152 aa
16.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.