Tissue expression of DCTN5 - Summary - The Human Protein Atlas

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DCTN5

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DCTN5
Gene description	Dynactin 5 (p25)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA042003
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DCTN5 (HGNC Symbol)
Synonyms	MGC3248, p25
Description	Dynactin 5 (p25) (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Chromosome	16
Cytoband	p12.2
Chromosome location (bp)	23641392 - 23677455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166847 (version 83.38)
Entrez gene	84516
UniProt	Q9BTE1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTE1
Antibodypedia	DCTN5 antibodies

PROTEIN BROWSER

DCTN5-001	DCTN5-003	DCTN5-004	DCTN5-005	DCTN5-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCTN5-001 ENSP00000300087 ENST00000300087	Q9BTE1 [Direct mapping] Dynactin subunit 5 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000777 [condensed chromosome kinetochore] GO:0003281 [ventricular septum development] GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0035904 [aorta development] GO:0060976 [coronary vasculature development] Show all	182 aa 20.1 kDa	No	0
DCTN5-003 ENSP00000455685 ENST00000568272	Q9BTE1 [Direct mapping] Dynactin subunit 5 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] Show all	84 aa 9.7 kDa	No	0
DCTN5-004 ENSP00000458354 ENST00000566298	I3L0U8 [Direct mapping] Dynactin subunit 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 11 kDa	No	0
DCTN5-005 ENSP00000456137 ENST00000568589	H3BR94 [Direct mapping] Dynactin subunit 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 16.9 kDa	No	0
DCTN5-009 ENSP00000454691 ENST00000563998	Q9BTE1 [Direct mapping] Dynactin subunit 5 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] Show all	152 aa 16.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.