Cell atlas - C15orf48 - The Human Protein Atlas

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C15orf48

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	C15orf48
Gene description	Chromosome 15 open reading frame 48
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Cell line enhanced (CAPAN-2, A-431)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA012677
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, A-431) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA012677	A549	Mitochondria
	HPA012677	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	C15orf48 (HGNC Symbol)
Synonyms	NMES1
Description	Chromosome 15 open reading frame 48 (HGNC Symbol)
Entrez gene summary	This gene was first identified in a study of human esophageal squamous cell carcinoma tissues. Levels of both the message and protein are reduced in carcinoma samples. In adult human tissues, this gene is expressed in the the esophagus, stomach, small intestine, colon and placenta. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jun 2012]
Chromosome	15
Cytoband	q21.1
Chromosome location (bp)	45430529 - 45448761
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166920 (version 83.38)
Entrez gene	84419
UniProt	Q9C002 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9C002
Antibodypedia	C15orf48 antibodies

PROTEIN BROWSER

C15orf48-001	C15orf48-002	C15orf48-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C15orf48-001 ENSP00000341610 ENST00000344300	Q9C002 [Direct mapping] Normal mucosa of esophagus-specific gene 1 protein A0A024R5U4 [Target identity:100%; Query identity:100%] Chromosome 15 open reading frame 48, isoform CRA_a Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005739 [mitochondrion] Show all	83 aa 9.6 kDa	No	0
C15orf48-002 ENSP00000379887 ENST00000396650	Q9C002 [Direct mapping] Normal mucosa of esophagus-specific gene 1 protein A0A024R5U4 [Target identity:100%; Query identity:100%] Chromosome 15 open reading frame 48, isoform CRA_a Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	83 aa 9.6 kDa	No	0
C15orf48-003 ENSP00000452967 ENST00000558435	H0YKW5 [Direct mapping] Normal mucosa of esophagus-specific gene 1 protein Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	132 aa 14.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.