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Most cancers showed moderate to strong cytoplasmic and nuclear positivity. Renal and liver cancers were weakly stained or negative in a few cases.
GENE INFORMATION
Gene name
CCNDBP1 (HGNC Symbol)
Synonyms
DIP1, GCIP
Description
Cyclin D-type binding-protein 1 (HGNC Symbol)
Entrez gene summary
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]
