Cell atlas - CCNDBP1 - The Human Protein Atlas

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CCNDBP1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CCNDBP1
Gene description	Cyclin D-type binding-protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Mouse	Localized to the Nucleus, Mitochondria in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA041065
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041065	A-431	Nucleoplasm
	HPA041065	HEK 293	Nucleoplasm
	HPA041065	U-2 OS	Nucleoplasm

MOUSE CELLS

Main location

Nucleus, Mitochondria

Mouse gene

ENSMUSG00000023572 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA041065	NIH 3T3	Nucleus
	HPA041065	NIH 3T3	Mitochondria

GENE INFORMATION
Gene name	CCNDBP1 (HGNC Symbol)
Synonyms	DIP1, GCIP
Description	Cyclin D-type binding-protein 1 (HGNC Symbol)
Entrez gene summary	This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]
Chromosome	15
Cytoband	q15.2
Chromosome location (bp)	43185118 - 43197176
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166946 (version 83.38)
Entrez gene	23582
UniProt	O95273 (UniProt - Evidence at protein level)
neXtProt	NX_O95273
Antibodypedia	CCNDBP1 antibodies

PROTEIN BROWSER

CCNDBP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCNDBP1-001 ENSP00000300213 ENST00000300213	O95273 [Direct mapping] Cyclin-D1-binding protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007049 [cell cycle] GO:0051726 [regulation of cell cycle] Show all	360 aa 40.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.