Expression of TGM6 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Transglutaminase 6

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA059196

GENE INFORMATION
Gene name	TGM6 (HGNC Symbol)
Synonyms	dJ734P14.3, SCA35, TGM3L, TGY
Description	Transglutaminase 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ataxia type 35 (SCA35). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	2380908 - 2432753
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166948 (version 83.38)
Entrez gene	343641
UniProt	O95932 (UniProt - Evidence at protein level)
neXtProt	NX_O95932
Antibodypedia	TGM6 antibodies

PROTEIN BROWSER

TGM6-001	TGM6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TGM6-001 ENSP00000202625 ENST00000202625	O95932 [Direct mapping] Protein-glutamine gamma-glutamyltransferase 6 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0003810 [protein-glutamine gamma-glutamyltransferase activity] GO:0005737 [cytoplasm] GO:0018149 [peptide cross-linking] GO:0046872 [metal ion binding] Show all	706 aa 79.3 kDa	No	0
TGM6-002 ENSP00000370831 ENST00000381423	O95932 [Direct mapping] Protein-glutamine gamma-glutamyltransferase 6 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0003810 [protein-glutamine gamma-glutamyltransferase activity] GO:0005737 [cytoplasm] GO:0018149 [peptide cross-linking] GO:0046872 [metal ion binding] Show all	625 aa 70.5 kDa	No	0