Tissue expression of TGM6 - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TGM6

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TGM6
Gene description	Transglutaminase 6
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Not detected
FANTOM5:	Tissue enriched (tonsil)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA059196
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (tonsil)

GENE INFORMATION
Gene name	TGM6 (HGNC Symbol)
Synonyms	dJ734P14.3, SCA35, TGM3L, TGY
Description	Transglutaminase 6 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ataxia type 35 (SCA35). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	2380908 - 2432753
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166948 (version 83.38)
Entrez gene	343641
UniProt	O95932 (UniProt - Evidence at protein level)
neXtProt	NX_O95932
Antibodypedia	TGM6 antibodies

PROTEIN BROWSER

TGM6-001	TGM6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TGM6-001 ENSP00000202625 ENST00000202625	O95932 [Direct mapping] Protein-glutamine gamma-glutamyltransferase 6 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0003810 [protein-glutamine gamma-glutamyltransferase activity] GO:0005737 [cytoplasm] GO:0018149 [peptide cross-linking] GO:0046872 [metal ion binding] Show all	706 aa 79.3 kDa	No	0
TGM6-002 ENSP00000370831 ENST00000381423	O95932 [Direct mapping] Protein-glutamine gamma-glutamyltransferase 6 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Show all	GO:0003810 [protein-glutamine gamma-glutamyltransferase activity] GO:0005737 [cytoplasm] GO:0018149 [peptide cross-linking] GO:0046872 [metal ion binding] Show all	625 aa 70.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.