Cell atlas - MAP1A - The Human Protein Atlas

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MAP1A

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	MAP1A
Gene description	Microtubule-associated protein 1A
Protein class	FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (U-87 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA066488
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066488	BJ	Cytosol
	HPA066488	RH-30	Cytosol
	HPA066488	U-2 OS	Cytosol	Intensity

GENE INFORMATION
Gene name	MAP1A (HGNC Symbol)
Synonyms	MAP1L
Description	Microtubule-associated protein 1A (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q15.3
Chromosome location (bp)	43510958 - 43531620
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166963 (version 83.38)
Entrez gene	4130
UniProt	P78559 (UniProt - Evidence at protein level)
neXtProt	NX_P78559
Antibodypedia	MAP1A antibodies

PROTEIN BROWSER

MAP1A-001	MAP1A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP1A-001 ENSP00000300231 ENST00000300231	P78559 [Direct mapping] Microtubule-associated protein 1A MAP1A heavy chain MAP1 light chain LC2 Show all	Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0001750 [photoreceptor outer segment] GO:0002230 [positive regulation of defense response to virus by host] GO:0003779 [actin binding] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005875 [microtubule associated complex] GO:0007026 [negative regulation of microtubule depolymerization] GO:0007605 [sensory perception of sound] GO:0008017 [microtubule binding] GO:0045494 [photoreceptor cell maintenance] GO:0097481 [neuronal postsynaptic density] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	2803 aa 305.5 kDa	No	0
MAP1A-002 ENSP00000371462 ENST00000382031	E9PGC8 [Direct mapping] Microtubule-associated protein 1A Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		3041 aa 331.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.