Tissue expression of GNGT2 - Summary - The Human Protein Atlas

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GNGT2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GNGT2
Gene description	Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
Protein class	Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in cones in retina.

DATA RELIABILITY
Data reliability description	No internal RNA expression data available for correlation. External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Supported based on 1 antibody. HPA043381
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Eye

N/A

Retina

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	GNGT2 (HGNC Symbol)
Synonyms	GNG9
Description	Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 (HGNC Symbol)
Entrez gene summary	Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	49202791 - 49210574
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167083 (version 83.38)
Entrez gene	2793
UniProt	O14610 (UniProt - Evidence at transcript level)
neXtProt	NX_O14610
Antibodypedia	GNGT2 antibodies

PROTEIN BROWSER

GNGT2-001	GNGT2-002	GNGT2-003	GNGT2-004	GNGT2-005	GNGT2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNGT2-001 ENSP00000300406 ENST00000300406	O14610 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007602 [phototransduction] Show all	69 aa 7.7 kDa	No	0
GNGT2-002 ENSP00000422879 ENST00000511673	O14610 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007602 [phototransduction] Show all	69 aa 7.7 kDa	No	0
GNGT2-003 ENSP00000426022 ENST00000511277	O14610 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007602 [phototransduction] Show all	69 aa 7.7 kDa	No	0
GNGT2-004 ENSP00000423924 ENST00000515635	O14610 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007602 [phototransduction] Show all	69 aa 7.7 kDa	No	0
GNGT2-005 ENSP00000421710 ENST00000507680	O14610 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007602 [phototransduction] Show all	69 aa 7.7 kDa	No	0
GNGT2-006 ENSP00000420946 ENST00000503070	D6RDH5 [Direct mapping] Guanine nucleotide-binding protein subunit gamma Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0004871 [signal transducer activity] GO:0005834 [heterotrimeric G-protein complex] GO:0007186 [G-protein coupled receptor signaling pathway] Show all	88 aa 10 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.