Expression of COQ4 in cancer - Summary - The Human Protein Atlas

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COQ4

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TISSUE

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CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

Coenzyme Q4

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042945

GENE INFORMATION
Gene name	COQ4 (HGNC Symbol)
Synonyms	CGI-92
Description	Coenzyme Q4 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the coenzyme Q biosynthesis pathway. Coenzyme Q, an essential component of the electron transport chain, shuttles electrons between complexes I or II to complex III of the mitochondrial transport chain. This protein appears to play a structural role in stabilizing a complex that contains most of the coenzyme Q biosynthesis enzymes. Mutations in this gene are associated with mitochondrial disorders linked to coenzyme Q deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	128322536 - 128334072
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167113 (version 83.38)
Entrez gene	51117
UniProt	Q9Y3A0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3A0
Antibodypedia	COQ4 antibodies

PROTEIN BROWSER

COQ4-001	COQ4-003	COQ4-004	COQ4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COQ4-001 ENSP00000300452 ENST00000300452	Q9Y3A0 [Direct mapping] Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006744 [ubiquinone biosynthetic process] Show all	265 aa 29.7 kDa	No	0
COQ4-003 ENSP00000361966 ENST00000372875	Q5T4B9 [Direct mapping] Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all	GO:0006744 [ubiquinone biosynthetic process] Show all	151 aa 16.8 kDa	No	0
COQ4-004 ENSP00000477292 ENST00000609948	V9GZ09 [Direct mapping] Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Show all	Predicted intracellular proteins Show all	GO:0006744 [ubiquinone biosynthetic process] Show all	86 aa 9 kDa	No	0
COQ4-005 ENSP00000476323 ENST00000608951	V9GY32 [Direct mapping] Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Show all	Predicted intracellular proteins Show all	GO:0006744 [ubiquinone biosynthetic process] Show all	96 aa 10.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.