Cell atlas - COQ4 - The Human Protein Atlas

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COQ4

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	COQ4
Gene description	Coenzyme Q4
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA021406
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA021406	HaCaT	Mitochondria
	HPA021406	HeLa	Mitochondria
	HPA021406	U-2 OS	No staining

GENE INFORMATION
Gene name	COQ4 (HGNC Symbol)
Synonyms	CGI-92
Description	Coenzyme Q4 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the coenzyme Q biosynthesis pathway. Coenzyme Q, an essential component of the electron transport chain, shuttles electrons between complexes I or II to complex III of the mitochondrial transport chain. This protein appears to play a structural role in stabilizing a complex that contains most of the coenzyme Q biosynthesis enzymes. Mutations in this gene are associated with mitochondrial disorders linked to coenzyme Q deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	128322536 - 128334072
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167113 (version 83.38)
Entrez gene	51117
UniProt	Q9Y3A0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3A0
Antibodypedia	COQ4 antibodies

PROTEIN BROWSER

COQ4-001	COQ4-003	COQ4-004	COQ4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COQ4-001 ENSP00000300452 ENST00000300452	Q9Y3A0 [Direct mapping] Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006744 [ubiquinone biosynthetic process] Show all	265 aa 29.7 kDa	No	0
COQ4-003 ENSP00000361966 ENST00000372875	Q5T4B9 [Direct mapping] Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all	GO:0006744 [ubiquinone biosynthetic process] Show all	151 aa 16.8 kDa	No	0
COQ4-004 ENSP00000477292 ENST00000609948	V9GZ09 [Direct mapping] Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Show all	Predicted intracellular proteins Show all	GO:0006744 [ubiquinone biosynthetic process] Show all	86 aa 9 kDa	No	0
COQ4-005 ENSP00000476323 ENST00000608951	V9GY32 [Direct mapping] Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial Show all	Predicted intracellular proteins Show all	GO:0006744 [ubiquinone biosynthetic process] Show all	96 aa 10.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.