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Most cancer tissues showed moderate nuclear and cytoplasmic staining. Additional membranous staining was seen in adenocarcinomas. A few cases of pancreatic, cervical, ovarian cancers and lymphomas showed strong nuclear positivity.
GENE INFORMATION
Gene name
SP2 (HGNC Symbol)
Synonyms
KIAA0048
Description
Sp2 transcription factor (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001701 [in utero embryonic development] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006955 [immune response] GO:0035264 [multicellular organism growth] GO:0042826 [histone deacetylase binding] GO:0046872 [metal ion binding] GO:0048144 [fibroblast proliferation] GO:0048568 [embryonic organ development] GO:0072358 [cardiovascular system development]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0035264 [multicellular organism growth]
