Cell atlas - SP2 - The Human Protein Atlas

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SP2

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	SP2
Gene description	Sp2 transcription factor
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Vesicles (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA003357 , CAB010245
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to vesicles.

Main location

Nucleoplasm (validated)

Additional location

Vesicles (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB010245	A-431	Nucleoplasm
	CAB010245	A-431	Vesicles
	CAB010245	U-2 OS	Nucleoplasm
	CAB010245	U-2 OS	Vesicles
	CAB010245	U-251 MG	Nucleoplasm
	CAB010245	U-251 MG	Vesicles
	HPA003357	A-431	Nucleoplasm
	HPA003357	U-2 OS	Nucleus
	HPA003357	U-251 MG	Nucleus

GENE INFORMATION
Gene name	SP2 (HGNC Symbol)
Synonyms	KIAA0048
Description	Sp2 transcription factor (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.32
Chromosome location (bp)	47896150 - 47928957
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167182 (version 83.38)
Entrez gene	6668
UniProt	Q02086 (UniProt - Evidence at protein level)
neXtProt	NX_Q02086
Antibodypedia	SP2 antibodies

PROTEIN BROWSER

SP2-001	SP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SP2-001 ENSP00000365931 ENST00000376741	Q02086 [Direct mapping] Transcription factor Sp2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001701 [in utero embryonic development] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006955 [immune response] GO:0035264 [multicellular organism growth] GO:0042826 [histone deacetylase binding] GO:0046872 [metal ion binding] GO:0048144 [fibroblast proliferation] GO:0048568 [embryonic organ development] GO:0072358 [cardiovascular system development] Show all	613 aa 64.9 kDa	No	0
SP2-201 ENSP00000484898 ENST00000613139	Q9BRW5 [Direct mapping] SP2 protein; Transcription factor Sp2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0035264 [multicellular organism growth] Show all	249 aa 25.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.