Tissue expression of GPRC5B - Summary - The Human Protein Atlas

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GPRC5B

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GPRC5B
Gene description	G protein-coupled receptor, class C, group 5, member B
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (caudate)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, most abundant in CNS, kidney and testis.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA015247
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GPRC5B (HGNC Symbol)
Synonyms	RAIG-2
Description	G protein-coupled receptor, class C, group 5, member B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	19856691 - 19886167
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167191 (version 83.38)
Entrez gene	51704
UniProt	Q9NZH0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NZH0
Antibodypedia	GPRC5B antibodies

PROTEIN BROWSER

GPRC5B-001	GPRC5B-002	GPRC5B-003	GPRC5B-004	GPRC5B-006	GPRC5B-007	GPRC5B-008	GPRC5B-009	GPRC5B-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPRC5B-001 ENSP00000300571 ENST00000300571	Q9NZH0 [Direct mapping] G-protein coupled receptor family C group 5 member B A0A024QYX2 [Target identity:100%; Query identity:100%] G protein-coupled receptor, family C, group 5, member B, isoform CRA_a Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001664 [G-protein coupled receptor binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0004930 [G-protein coupled receptor activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007626 [locomotory behavior] GO:0009986 [cell surface] GO:0010976 [positive regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0032147 [activation of protein kinase activity] GO:0042593 [glucose homeostasis] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0045666 [positive regulation of neuron differentiation] GO:0045860 [positive regulation of protein kinase activity] GO:0050729 [positive regulation of inflammatory response] GO:0060907 [positive regulation of macrophage cytokine production] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	403 aa 44.8 kDa	Yes	7
GPRC5B-002 ENSP00000454727 ENST00000569479	Q9NZH0 [Direct mapping] G-protein coupled receptor family C group 5 member B A0A024QYX2 [Target identity:100%; Query identity:100%] G protein-coupled receptor, family C, group 5, member B, isoform CRA_a Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001664 [G-protein coupled receptor binding] GO:0004930 [G-protein coupled receptor activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0032147 [activation of protein kinase activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0045666 [positive regulation of neuron differentiation] GO:0050729 [positive regulation of inflammatory response] GO:0060907 [positive regulation of macrophage cytokine production] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	403 aa 44.8 kDa	Yes	7
GPRC5B-003 ENSP00000457283 ENST00000569847	Q9NZH0 [Direct mapping] G-protein coupled receptor family C group 5 member B A0A024QYX2 [Target identity:100%; Query identity:100%] G protein-coupled receptor, family C, group 5, member B, isoform CRA_a Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001664 [G-protein coupled receptor binding] GO:0004930 [G-protein coupled receptor activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0032147 [activation of protein kinase activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0045666 [positive regulation of neuron differentiation] GO:0050729 [positive regulation of inflammatory response] GO:0060907 [positive regulation of macrophage cytokine production] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	403 aa 44.8 kDa	Yes	7
GPRC5B-004 ENSP00000442858 ENST00000535671	Q9NZH0 [Direct mapping] G-protein coupled receptor family C group 5 member B Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001664 [G-protein coupled receptor binding] GO:0004930 [G-protein coupled receptor activity] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0030295 [protein kinase activator activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0032147 [activation of protein kinase activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043231 [intracellular membrane-bounded organelle] GO:0045666 [positive regulation of neuron differentiation] GO:0050729 [positive regulation of inflammatory response] GO:0060907 [positive regulation of macrophage cytokine production] GO:0061098 [positive regulation of protein tyrosine kinase activity] GO:0070062 [extracellular exosome] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	404 aa 44.9 kDa	Yes	7
GPRC5B-006 ENSP00000457018 ENST00000564449	H3BT47 [Direct mapping] G-protein-coupled receptor family C group 5 member B Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		26 aa 3 kDa	No	0
GPRC5B-007 ENSP00000456724 ENST00000570142	H3BSJ1 [Direct mapping] G-protein-coupled receptor family C group 5 member B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	86 aa 9.3 kDa	Yes	1
GPRC5B-008 ENSP00000454667 ENST00000566822	H3BN33 [Direct mapping] G-protein-coupled receptor family C group 5 member B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	178 aa 19.6 kDa	Yes	4
GPRC5B-009 ENSP00000455960 ENST00000562469	H3BQV9 [Direct mapping] G-protein-coupled receptor family C group 5 member B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	148 aa 16.5 kDa	Yes	3
GPRC5B-010 ENSP00000457080 ENST00000568214	H3BT93 [Direct mapping] G-protein-coupled receptor family C group 5 member B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	90 aa 9.9 kDa	Yes	1

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