Expression of CRK in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

V-crk avian sarcoma virus CT10 oncogene homolog

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB010485

GENE INFORMATION
Gene name	CRK
Synonyms
Description	V-crk avian sarcoma virus CT10 oncogene homolog (HGNC Symbol)
Entrez gene summary	This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	1420689 - 1463162
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167193 (version 83.38)
Entrez gene	1398
UniProt	P46108 (UniProt - Evidence at protein level)
neXtProt	NX_P46108
Antibodypedia	CRK antibodies

PROTEIN BROWSER

CRK-001	CRK-002	CRK-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRK-001 ENSP00000300574 ENST00000300574	P46108 [Direct mapping] Adapter molecule crk L7RT18 [Target identity:100%; Query identity:100%] V-crk sarcoma virus CT10 oncogene homolog (Avian) Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007596 [blood coagulation] GO:0009967 [positive regulation of signal transduction] GO:0015629 [actin cytoskeleton] GO:0019904 [protein domain specific binding] GO:0030168 [platelet activation] GO:0030674 [protein binding, bridging] GO:0032956 [regulation of actin cytoskeleton organization] GO:0035020 [regulation of Rac protein signal transduction] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042169 [SH2 domain binding] GO:0043087 [regulation of GTPase activity] GO:0045087 [innate immune response] GO:0045309 [protein phosphorylated amino acid binding] GO:0046875 [ephrin receptor binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	304 aa 33.8 kDa	No	0
CRK-002 ENSP00000381942 ENST00000398970	P46108 [Direct mapping] Adapter molecule crk Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007596 [blood coagulation] GO:0030168 [platelet activation] GO:0032956 [regulation of actin cytoskeleton organization] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042169 [SH2 domain binding] GO:0043087 [regulation of GTPase activity] GO:0045087 [innate immune response] GO:0046875 [ephrin receptor binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	204 aa 22.9 kDa	No	0
CRK-003 ENSP00000459505 ENST00000574295	I3L297 [Direct mapping] Adapter molecule crk Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		223 aa 25.5 kDa	No	0