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LALBA

CANCER ATLAS

Gene description

 Lactalbumin, alpha-

Protein class

 Cancer-related genes, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029855
HPA029856
CAB026343

GENE INFORMATION

Gene name

 LALBA (HGNC Symbol)

Synonyms

 LYZL7

Description

 Lactalbumin, alpha- (HGNC Symbol)

Entrez gene summary

 This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.11

Chromosome location (bp)

 48567684 - 48570066

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167531 (version 83.38)

Entrez gene

 3906

UniProt

 P00709 (UniProt - Evidence at protein level)

neXtProt

 NX_P00709

Antibodypedia

 LALBA antibodies

PROTEIN BROWSER
LALBA-001
LALBA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LALBA-001
ENSP00000301046
ENST00000301046
P00709 [Direct mapping]
Alpha-lactalbumin
A0A080YV01 [Target identity:100%; Query identity:100%]
Lysozyme G
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000139 [Golgi membrane]
GO:0004461 [lactose synthase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0005989 [lactose biosynthetic process]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0042742 [defense response to bacterium]
GO:0044281 [small molecule metabolic process]
Show all
 142 aa
16.2 kDa 		Yes 0
LALBA-002
ENSP00000449780
ENST00000549817
F8VWU1 [Direct mapping]
Alpha-lactalbumin
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004461 [lactose synthase activity]
GO:0005509 [calcium ion binding]
GO:0005989 [lactose biosynthetic process]
Show all
 123 aa
14 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.