Cell atlas - SPINT2 - The Human Protein Atlas

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SPINT2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Intermediate filaments
	Plasma membrane

Human cell
	Cytosol
	Intermediate Filaments
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SPINT2
Gene description	Serine peptidase inhibitor, Kunitz type, 2
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane, cytosol & intermediate filaments.
RNA cell category	Cell line enhanced (CAPAN-2, A-431)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (uncertain), Intermediate filaments (uncertain), Cytosol (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Uncertain based on 2 antibodies. HPA011101 , CAB018969
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, A-431) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane, cytosol & intermediate filaments.

Main location

Plasma membrane (uncertain), Intermediate filaments (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011101	A-431	Intermediate filaments	Intensity
	HPA011101	U-2 OS	Intermediate filaments
	HPA011101	U-251 MG	Plasma membrane
	HPA011101	U-251 MG	Cytosol
	CAB018969	A-431	Cytosol
	CAB018969	U-2 OS	No staining
	CAB018969	U-251 MG	No staining

GENE INFORMATION
Gene name	SPINT2 (HGNC Symbol)
Synonyms	HAI-2, Kop
Description	Serine peptidase inhibitor, Kunitz type, 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	38244035 - 38292614
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167642 (version 83.38)
Entrez gene	10653
UniProt	O43291 (UniProt - Evidence at protein level)
neXtProt	NX_O43291
Antibodypedia	SPINT2 antibodies

PROTEIN BROWSER

SPINT2-001	SPINT2-002	SPINT2-004	SPINT2-005	SPINT2-006	SPINT2-009	SPINT2-010	SPINT2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPINT2-001 ENSP00000301244 ENST00000301244	O43291 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001843 [neural tube closure] GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006928 [movement of cell or subcellular component] GO:0007163 [establishment or maintenance of cell polarity] GO:0010951 [negative regulation of endopeptidase activity] GO:0016021 [integral component of membrane] GO:0022408 [negative regulation of cell-cell adhesion] GO:0060672 [epithelial cell morphogenesis involved in placental branching] GO:0071711 [basement membrane organization] GO:0071773 [cellular response to BMP stimulus] GO:2000146 [negative regulation of cell motility] GO:2000178 [negative regulation of neural precursor cell proliferation] Show all	252 aa 28.2 kDa	Yes	1
SPINT2-002 ENSP00000389788 ENST00000454580	O43291 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006928 [movement of cell or subcellular component] GO:0010951 [negative regulation of endopeptidase activity] GO:0016021 [integral component of membrane] GO:0022408 [negative regulation of cell-cell adhesion] GO:2000146 [negative regulation of cell motility] Show all	195 aa 21.8 kDa	Yes	1
SPINT2-004 ENSP00000466407 ENST00000587090	K7EM91 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0016021 [integral component of membrane] Show all	202 aa 22.8 kDa	No	1
SPINT2-005 ENSP00000465561 ENST00000592007	K7EKC8 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	62 aa 6.7 kDa	No	0
SPINT2-006 ENSP00000465721 ENST00000587516	K7EKQ0 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	175 aa 19.8 kDa	Yes	0
SPINT2-009 ENSP00000468728 ENST00000590738	K7ESI5 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005634 [nucleus] GO:0010951 [negative regulation of endopeptidase activity] Show all	130 aa 14.7 kDa	No	0
SPINT2-010 ENSP00000468519 ENST00000587334	K7ES27 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	106 aa 11.2 kDa	No	1
SPINT2-011 ENSP00000465301 ENST00000590510	K7EJS4 [Direct mapping] Kunitz-type protease inhibitor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	52 aa 5.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.